| Named By: | Charles Lewis Camp in 1942 |
| Time Period: | Late Cretaceous, 70 Ma |
| Location: | USA - California - Moreno Formation |
| Size: | Holotype skull about 90 centimetres long, estimated total length roughly 6.5 meters long |
| Diet: | Carnivore/Piscivore |
| Fossil(s): | Skull and jaw |
| Classification: | | Chordata | Reptilia | Squamata | Mosasauridae | Mosasaurinae | |
Plesiotylosaurus is a genus of mosasaur from the Maastrichtian stage of the Late Cretaceous of North America.