| Named By: | Florentino Ameghino in 1882 |
| Time Period: | Miocene (Deseadan-Huayquerian)~23.03-6.8 Ma |
| Location: | South America, particularly Argentina |
| Size: | 40 centimetres long |
| Diet: | Herbivore/carnivore |
| Fossil(s): | Several individuals |
| Classification: | | Chordata | Mammalia | Notoungulata | Typotheria | Interatheriidae | |
Protypotherium is an extinct genus of notoungulate mammals native to South America during the Miocene epoch. A number of closely related animals date back further, to the Paleocene. Fossils of Protypotherium have been found in the Deseadan Fray Bentos Formation of Uruguay, Muyu Huasi Formation of Bolivia, Cura-Mallin and Rio Frias Formations of Chile and Santa Cruz, Salicas, Ituzaingo, Cerro Bandera, Chichinales, Sarmiento and Collon-Cura Formations of Argentina.