| Named By: | William Diller Matthew in 1907 |
| Time Period: | Miocene |
| Location: | USA |
| Size: | Estimated between 20 and 60 kilograms, but opinions amongst palaeontologists can vary greatly |
| Diet: | Carnivore |
| Fossil(s): | Multiple individuals |
| Classification: | | Chordata | Mammalia | Carnivora | Mustelidae | Oligobuninae | |
| Also known as: | | Aelurocyon brevifacies | Brachypsalis simplicidens | Megalictis brevifacies | Megalictis simplicidens | Paroligobunis | simplicidens | |
Megalictis (great weasel) is an extinct genus of large predatory mustelids, which existed in North America during the "cat gap" in the Miocene period. It is thought to have resembled a large wolverine, with a body mass of up to 60 kilograms (130 lb).